Details

Autor(en) / Beteiligte

• Gandal, Michael J
• Haney, Jillian R
• Parikshak, Neelroop N
• Leppa, Virpi
• Ramaswami, Gokul
• Hartl, Chris
• Schork, Andrew J
• Appadurai, Vivek
• Buil, Alfonso
• Werge, Thomas M
• Liu, Chunyu
• White, Kevin P
• Horvath, Steve
• Geschwind, Daniel H

Titel

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

Ist Teil von

• Science (American Association for the Advancement of Science), 2018-02, Vol.359 (6376), p.693-697

Ort / Verlag

United States: The American Association for the Advancement of Science

Erscheinungsjahr

2018

Link zum Volltext

Quelle

Science Online_科学在线

Beschreibungen/Notizen

• The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders-autism, schizophrenia, bipolar disorder, depression, and alcoholism-compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism-based) overlap across disorders, suggesting a substantial causal genetic component. This comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity.