Details

Autor(en) / Beteiligte

• Oudin, Claire
• Berbis, Julie
• Bertrand, Yves
• Vercasson, Camille
• Thomas, Frédérique
• Chastagner, Pascal
• Ducassou, Stéphane
• Kanold, Justyna
• Tabone, Marie-Dominique
• Paillard, Catherine
• Poirée, Marilyne
• Plantaz, Dominique
• Dalle, Jean-Hugues
• Gandemer, Virginie
• Thouvenin, Sandrine
• Sirvent, Nicolas
• Saultier, Paul
• Béliard, Sophie
• Leverger, Guy
• Baruchel, André
• Auquier, Pascal
• Pannier, Bruno
• Michel, Gérard

Titel

Prevalence and characteristics of metabolic syndrome in adults from the French childhood leukemia survivors' cohort: a comparison with controls from the French population

Ist Teil von

• Haematologica (Roma), 2018-04, Vol.103 (4), p.645-654

Ort / Verlag

Italy: Ferrata Storti Foundation

Erscheinungsjahr

2018

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The prevalence of the metabolic syndrome among adults from the French LEA childhood acute leukemia survivors' cohort was prospectively evaluated considering the type of anti-leukemic treatment received, and compared with that of controls. The metabolic profile of these patients was compared with that of controls. A total of 3203 patients from a French volunteer cohort were age- and sex-matched 3:1 to 1025 leukemia survivors (in both cohorts, mean age: 24.4 years; females: 51%). Metabolic syndrome was defined according to the National Cholesterol Education Program's Adult Treatment Panel III criteria. Metabolic syndrome was found in 10.3% of patients (mean follow-up duration: 16.3±0.2 years) and 4.5% of controls, (OR=2.49; <0.001). Patients transplanted with total body irradiation presented the highest risk (OR=6.26; <0.001); the other treatment groups also showed a higher risk than controls, including patients treated with chemotherapy only. Odd Ratios were 1.68 ( =0.005) after chemotherapy only, 2.32 ( =0.002) after chemotherapy and cranial irradiation, and 2.18 ( =0.057) in patients transplanted without irradiation. Total body irradiation recipients with metabolic syndrome displayed a unique profile compared with controls: smaller waist circumference (91 99.6 cm; =0.01), and increased triglyceride levels (3.99 1.5 mmol/L; <0.001), fasting glucose levels (6.2 5.6 mmol/L; =0.049), and systolic blood pressure (137.9 132.8 mmHg; =0.005). By contrast, cranial irradiation recipients with metabolic syndrome had a larger waist circumference (109 99.6 cm; =0.007) than controls. Regardless of the anti-leukemic treatment, metabolic syndrome risk was higher among childhood leukemia survivors. Its presentation differed depending on the treatment type, thus suggesting a divergent pathophysiology. This study is registered at .