Details

Autor(en) / Beteiligte

• Boritz, Eli A.
• Douek, Daniel C.

Titel

Perspectives on Human Immunodeficiency Virus (HIV) Cure: HIV Persistence in Tissue

Ist Teil von

• The Journal of infectious diseases, 2017-03, Vol.215 (suppl_3), p.S128-S133

Ort / Verlag

US: Oxford University Press

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The uneven anatomic distribution of cell subsets that harbor human immunodeficiency virus (HIV) during antiretroviral therapy (ART) complicates investigation of the barriers to HIV cure. Here we propose that while previous studies done largely in blood cells have led to important investigations into HIV latency, other important mechanisms of HIV persistence during ART may not be readily apparent in the bloodstream. We specifically consider as an example the question of ongoing HIV replication during ART. We discuss how growing understanding of key anatomic sanctuaries for the virus can inform future experiments aimed at further clarifying this issue.