Details

Autor(en) / Beteiligte

• Yang, Xinxing
• Lyu, Zhixin
• Miguel, Amanda
• McQuillen, Ryan
• Huang, Kerwyn Casey
• Xiao, Jie

Titel

GTPase activity–coupled treadmilling of the bacterial tubulin FtsZ organizes septal cell wall synthesis

Ist Teil von

• Science (American Association for the Advancement of Science), 2017-02, Vol.355 (6326), p.744-747

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2017

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• The bacterial tubulin FtsZ is the central component of the cell division machinery, coordinating an ensemble of proteins involved in septal cell wall synthesis to ensure successful constriction. How cells achieve this coordination is unknown. We found that in Escherichia coli cells, FtsZ exhibits dynamic treadmilling predominantly determined by its guanosine triphosphatase activity. The treadmilling dynamics direct the processive movement of the septal cell wall synthesis machinery but do not limit the rate of septal synthesis. In FtsZ mutants with severely reduced treadmilling, the spatial distribution of septal synthesis and the molecular composition and ultrastructure of the septal cell wall were substantially altered. Thus, FtsZ treadmilling provides a mechanism for achieving uniform septal cell wall synthesis to enable correct polar morphology.