Details

Autor(en) / Beteiligte

• Zangerle, Robert
• Touloumi, Giota
• Warszawski, Josiane
• Meyer, Laurence
• Dabis, François
• Leport, Catherine
• Gibb, Diana
• Obel, Niels
• Thorne, Claire
• Bartmeyer, Barbara
• Chkhartishvili, Nikoloz
• Noguera-Julian, Antoni
• d’Arminio Monforte, Antonella
• Casabona, Jordi
• Miró, Jose M
• Goetghebuer, Tessa
• Haerry, David
• Dunn, David
• Matheron, Sophie
• Puoti, Massimo
• Rohner, Eliane
• Tanser, Frank
• Malisita, Kennedy
• Sawry, Shobna
• Boswell, Stephen
• Grasso, Chris
• Brooks, John T
• Gebo, Kelly A
• Horberg, Michael A
• Silverberg, Michael J
• Rabkin, Charles
• Jacobson, Lisa P
• Cupido, Patrick
• Mayor, Angel M
• Bebawy, Sally
• Althoff, Keri N
• McKaig, Rosemary G
• Lent, Carol
• Lau, Bryan
• Zhang, Jinbing
• Wong, Cherise
• Fink, Valeria
• Sued, Omar
• Perez, Hector
• Luz, Paula
• de Boni, Raquel
• Friedman, Ruth
• Maria Machado, Daisy
• Cortes, Claudia
• Marcelin, Adias
• Sierra Madero, Juan
• Carriquiry, Gabriela
• McGowan, Catherine C
• Sterling, Timothy
• Giganti, Mark
• Castilho, Jessica
• Duda, Stephany N
• Ly, P S
• Zhao, H X
• Lam, W
• Kumarasamy, N
• Saghayam, S
• Ezhilarasi, C
• Joshi, K
• Merati, T P
• Oka, S
• Choi, J Y
• Syed Omar, S F
• Ponnampalavanar, S
• Wong, W W
• Lee, L S
• Chaiwarith, R
• Praparattanapan, J
• Nguyen, D T H
• Cuong, D D
• Sohn, A H
• Boettiger, D C
• Ellis, D
• Allen, D
• Rankin, A
• O’Connor, C C
• Carr, A
• Langton-Lockton, J
• Shakeshaft, J
• Varma, R
• Han, A
• Gunathilake, M
• Roberts, C
• Sowden, D
• Taing, K
• Marshall, P
• Youds, D
• Read, T
• Silvers, J
• Bryant, M
• Giles, M
• Nolan, D
• Allen, A
• Mills, G
• Bargh, K

Titel

Comparison of Kaposi Sarcoma Risk in Human Immunodeficiency Virus-Positive Adults Across 5 Continents: A Multiregional Multicohort Study

Ist Teil von

• Clinical infectious diseases, 2017-10, Vol.65 (8), p.1316-1326

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background. We compared Kaposi sarcoma (KS) risk in adults who started antiretroviral therapy (ART) across the Asia-Pacific, South Africa, Europe, Latin, and North America. Methods. We included cohort data of human immunodeficiency virus (HIV)–positive adults who started ART after 1995 within the framework of 2 large collaborations of observational HIV cohorts. We present incidence rates and adjusted hazard ratios (aHRs). Results. We included 208 140 patients from 57 countries. Over a period of 1 066 572 person-years, 2046 KS cases were diagnosed. KS incidence rates per 100 000 person-years were 52 in the Asia-Pacific and ranged between 180 and 280 in the other regions. KS risk was 5 times higher in South African women (aHR, 4.56; 95% confidence intervals [CI], 2.73–7.62) than in their European counterparts, and 2 times higher in South African men (2.21; 1.34–3.63). In Europe, Latin, and North America KS risk was 6 times higher in men who have sex with men (aHR, 5.95; 95% CI, 5.09–6.96) than in women. Comparing patients with current CD4 cell counts ≥700 cells/μL with those whose counts were <50 cells/μL, the KS risk was halved in South Africa (aHR, 0.53; 95% CI, .17–1.63) but reduced by ≥95% in other regions. Conclusions. Despite important ART-related declines in KS incidence, men and women in South Africa and men who have sex with men remain at increased KS risk, likely due to high human herpesvirus 8 coinfection rates. Early ART initiation and maintenance of high CD4 cell counts are essential to further reducing KS incidence worldwide, but additional measures might be needed, especially in Southern Africa.