Details

Autor(en) / Beteiligte

• Xiao, Xuelian
• Yang, Daheng
• Gong, Xue
• Mo, Dongping
• Pan, Shiyang
• Xu, Jian

Titel

miR-1290 promotes lung adenocarcinoma cell proliferation and invasion by targeting SOCS4

Ist Teil von

• Oncotarget, 2018-02, Vol.9 (15), p.11977-11988

Ort / Verlag

United States: Impact Journals LLC

Erscheinungsjahr

2018

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• miRNAs play important roles in lung adenocarcioma (LADC) progression. We previously found that miR-1290 expression was upregulated in LADC tissue and serum samples from patients with LADC, and correlated with prognosis. However, the biological role of miR-1290 in LADC and mechanism of such role are poorly understood. Here, we found that miR-1290 overexpression promoted LADC cell proliferation, cell cycle progression and invasion, while suppressing cell apoptosis . Furthermore, miR-1290 promoted tumor growth, invasion and metastasis . miR-1290 downregulated suppressor of cytokine signaling 4 (SOCS4) at both the mRNA and protein levels by targeting SOCS4. Reduced SOCS4 level reversed the inhibitory effect of miR-1290 downregulation on cell proliferation and invasion. miR-1290 activated the JAK/STAT3 and PI3K/AKT signaling pathways by targeting SOCS4. An inverse correlation was observed between miR-1290 and SOCS4 expression in LADC tissues. Clinicopathological characteristics analysis showed that SOCS4 expression was negatively associated with higher clinical stage and lymph node metastasis. These observations suggest that miR-1290 promotes LADC cell proliferation and invasion by targeting SOCS4.