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Therapeutic potential of phages in autoimmune liver diseases
Ist Teil von
Clinical and experimental immunology, 2018-04, Vol.192 (1), p.1-6
Ort / Verlag
England: Oxford University Press
Erscheinungsjahr
2018
Quelle
MEDLINE
Beschreibungen/Notizen
Summary
Autoimmune liver disease (ALD) poses a difficult medical challenge, as there is a significant number of patients in whom current therapy offers questionable or no benefit, yet its side effects may be serious, including the development of malignancy. Bacterial viruses (phages) have been recognized increasingly as immunomodulators contributing to immune homeostasis and curbing inflammation. Accumulating data suggest that phages may be useful in immunotherapy of ALD. Phages have been shown to down‐regulate the expression and/or production and activity of factors associated with hepatic injury [reactive oxygen species, Toll‐like receptor (TLR)‐4 activation, nuclear factor kappa B (NF‐κB) activation, proinflammatory and procoagulant activities of platelets] and up‐regulate the expression and/or production of factors demonstrated as playing a protective role [interleukin (IL)‐10, IL‐1 receptor antagonist].
Phage‐mediated changes in immune parameters which may be beneficial in the treatment of autoimmune liver disease.