Details

Autor(en) / Beteiligte

• Górski, A.
• Jończyk‐Matysiak, E.
• Łusiak‐Szelachowska, M.
• Weber‐Dąbrowska, B.
• Międzybrodzki, R.
• Borysowski, J.

Titel

Therapeutic potential of phages in autoimmune liver diseases

Ist Teil von

• Clinical and experimental immunology, 2018-04, Vol.192 (1), p.1-6

Ort / Verlag

England: Oxford University Press

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary Autoimmune liver disease (ALD) poses a difficult medical challenge, as there is a significant number of patients in whom current therapy offers questionable or no benefit, yet its side effects may be serious, including the development of malignancy. Bacterial viruses (phages) have been recognized increasingly as immunomodulators contributing to immune homeostasis and curbing inflammation. Accumulating data suggest that phages may be useful in immunotherapy of ALD. Phages have been shown to down‐regulate the expression and/or production and activity of factors associated with hepatic injury [reactive oxygen species, Toll‐like receptor (TLR)‐4 activation, nuclear factor kappa B (NF‐κB) activation, proinflammatory and procoagulant activities of platelets] and up‐regulate the expression and/or production of factors demonstrated as playing a protective role [interleukin (IL)‐10, IL‐1 receptor antagonist]. Phage‐mediated changes in immune parameters which may be beneficial in the treatment of autoimmune liver disease.