Details

Autor(en) / Beteiligte

• Verdaguer, Mar Guasp
• Solà-Valls, Nuria
• Martínez-Hernández, Eugenia
• Villar, M Pilar Gil
• Mingot, Cristina González
• Ruiz, Luis Brieva
• Saiz, Albert
• Dalmau, Josep
• Graus, Francesc
• Ariño, Helena

Titel

Cerebellar ataxia and autoantibodies restricted to glutamic acid decarboxylase 67 (GAD67)

Ist Teil von

• Journal of neuroimmunology, 2016-11, Vol.300, p.15-17

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2016

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Cerebellar ataxia is one of the most frequent syndromes associated with autoantibodies against glutamic acid decarboxylase (GAD-ab). Antibodies recognize the isoform GAD65, which is the standard biomarker, but additional immunoreactivity against GAD67 is found in high proportion of patients with GAD-ab-associated neurological disorders. We describe the case of a 59-year-old woman who presented with pancerebellar syndrome of subacute onset (9 weeks to nadir). In the etiological study, high titers of GAD-ab were found, but these only recognized the GAD67 isoform and not the GAD65. Screening of GAD67-ab should be considered in late-onset cerebellar ataxia when GAD65-ab are absent.