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Pulse duration settings in subthalamic stimulation for Parkinson's disease
Movement disorders, 2018-01, Vol.33 (1), p.165-169
Steigerwald, Frank
Timmermann, Lars
Kühn, Andrea
Schnitzler, Alfons
Reich, Martin M.
Kirsch, Anna Dalal
Barbe, Michael Thomas
Visser‐Vandewalle, Veerle
Hübl, Julius
van Riesen, Christoph
Groiss, Stefan Jun
Moldovan, Alexia‐Sabine
Lin, Sherry
Carcieri, Stephen
Manola, Ljubomir
Volkmann, Jens
2018
Details
Autor(en) / Beteiligte
Steigerwald, Frank
Timmermann, Lars
Kühn, Andrea
Schnitzler, Alfons
Reich, Martin M.
Kirsch, Anna Dalal
Barbe, Michael Thomas
Visser‐Vandewalle, Veerle
Hübl, Julius
van Riesen, Christoph
Groiss, Stefan Jun
Moldovan, Alexia‐Sabine
Lin, Sherry
Carcieri, Stephen
Manola, Ljubomir
Volkmann, Jens
Titel
Pulse duration settings in subthalamic stimulation for Parkinson's disease
Ist Teil von
Movement disorders, 2018-01, Vol.33 (1), p.165-169
Ort / Verlag
United States: Wiley Subscription Services, Inc
Erscheinungsjahr
2018
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
ABSTRACT Background Stimulation parameters in deep brain stimulation (DBS) of the subthalamic nucleus for Parkinson's disease (PD) are rarely tested in double‐blind conditions. Evidence‐based recommendations on optimal stimulator settings are needed. Results from the CUSTOM‐DBS study are reported, comparing 2 pulse durations. Methods A total of 15 patients were programmed using a pulse width of 30 µs (test) or 60 µs (control). Efficacy and side‐effect thresholds and unified PD rating scale (UPDRS) III were measured in meds‐off (primary outcome). The therapeutic window was the difference between patients’ efficacy and side effect thresholds. Results The therapeutic window was significantly larger at 30 µs than 60 µs (P = ·0009) and the efficacy (UPDRS III score) was noninferior (P = .00008). Interpretation Subthalamic neurostimulation at 30 µs versus 60 µs pulse width is equally effective on PD motor signs, is more energy efficient, and has less likelihood of stimulation‐related side effects. © 2017 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.27238
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5813170
Format
–
Schlagworte
Aged
,
Biophysical Phenomena - physiology
,
Biophysics
,
Brief Report
,
Brief Reports
,
Deep brain stimulation
,
Deep Brain Stimulation - methods
,
Double-Blind Method
,
Electrical stimuli
,
Electrodes, Implanted
,
Female
,
Humans
,
Male
,
Middle Aged
,
Movement disorders
,
Neurodegenerative diseases
,
Parkinson Disease - therapy
,
Parkinson's disease
,
Parkinsons disease
,
pulse width
,
Severity of Illness Index
,
Side effects
,
stimulation parameters
,
subthalamic
,
Subthalamic nucleus
,
Subthalamic Nucleus - physiology
,
Time Factors
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