Details

Autor(en) / Beteiligte

• Martinez-Martin, Nuria
• Maldonado, Paula
• Gasparrini, Francesca
• Frederico, Bruno
• Aggarwal, Shweta
• Gaya, Mauro
• Tsui, Carlson
• Burbage, Marianne
• Keppler, Selina Jessica
• Montaner, Beatriz
• Jefferies, Harold B. J.
• Nair, Usha
• Zhao, Yan G.
• Domart, Marie-Charlotte
• Collinson, Lucy
• Bruckbauer, Andreas
• Tooze, Sharon A.
• Batista, Facundo D.

Titel

A switch from canonical to noncanonical autophagy shapes B cell responses

Ist Teil von

• Science (American Association for the Advancement of Science), 2017-02, Vol.355 (6325), p.641-647

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Autophagy is important in a variety of cellular and pathophysiological situations; however, its role in immune responses remains elusive. Here, we show that among B cells, germinal center (GC) cells exhibited the highest rate of autophagy during viral infection. In contrast to mechanistic target of rapamycin complex 1–dependent canonical autophagy, GC B cell autophagy occurred predominantly through a noncanonical pathway. B cell stimulation was sufficient to down-regulate canonical autophagy transiently while triggering noncanonical autophagy. Genetic ablation of WD repeat domain, phosphoinositide–interacting protein 2 in B cells alone enhanced this noncanonical autophagy, resulting in changes of mitochondrial homeostasis and alterations in GC and antibody-secreting cells. Thus, B cell activation prompts a temporal switch from canonical to noncanonical autophagy that is important in controlling B cell differentiation and fate.