Details

Autor(en) / Beteiligte

• Carrington, Lauren B.
• Tran, Bich Chau Nguyen
• Le, Nhat Thanh Hoang
• Luong, Tai Thi Hue
• Nguyen, Truong Thanh
• Nguyen, Phong Thanh
• Van Vinh Nguyen, Chau
• Nguyen, Huong Thi Cam
• Vu, Trung Tuan
• Vo, Long Thi
• Le, Dui Thi
• Vu, Nhu Tuyet
• Nguyen, Giang Thi
• Luu, Hung Quoc
• Dang, Anh Duc
• Hurst, Timothy P.
• O’Neill, Scott L.
• Tran, Vi Thuy
• Kien, Duong Thi Hue
• Nguyen, Nguyet Minh
• Wolbers, Marcel
• Wills, Bridget
• Simmons, Cameron P.

Titel

Field- and clinically derived estimates of Wolbachia-mediated blocking of dengue virus transmission potential in Aedes aegypti mosquitoes

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (2), p.361-366

Ort / Verlag

United States: National Academy of Sciences

Erscheinungsjahr

2018

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The wMel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of wMel introgression for the biocontrol of Ae. aegypti-born arboviruses.