Details

Autor(en) / Beteiligte

• Khalighi, Mohammad Mehdi
• Deller, Timothy W
• Fan, Audrey Peiwen
• Gulaka, Praveen K
• Shen, Bin
• Singh, Prachi
• Park, Jun-Hyung
• Chin, Frederick T
• Zaharchuk, Greg

Titel

Image-derived input function estimation on a TOF-enabled PET/MR for cerebral blood flow mapping

Ist Teil von

• Journal of cerebral blood flow and metabolism, 2018-01, Vol.38 (1), p.126-135

Ort / Verlag

London, England: SAGE Publications

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• 15O-H2O PET imaging is an accurate method to measure cerebral blood flow (CBF) but it requires an arterial input function (AIF). Historically, image-derived AIF estimation suffers from low temporal resolution, spill-in, and spill-over problems. Here, we optimized tracer dose on a time-of-flight PET/MR according to the acquisition-specific noise-equivalent count rate curve. An optimized dose of 850 MBq of 15O-H2O was determined, which allowed sufficient counts to reconstruct a short time-frame PET angiogram (PETA) during the arterial phase. This PETA enabled the measurement of the extent of spill-over, while an MR angiogram was used to measure the true arterial volume for AIF estimation. A segment of the high cervical arteries outside the brain was chosen, where the measured spill-in effects were minimal. CBF studies were performed twice with separate [15O]-H2O injections in 10 healthy subjects, yielding values of 88 ± 16, 44 ± 9, and 58 ± 11 mL/min/100 g for gray matter, white matter, and whole brain, with intra-subject CBF differences of 5.0 ± 4.0%, 4.1 ± 3.3%, and 4.5 ± 3.7%, respectively. A third CBF measurement after the administration of 1 g of acetazolamide showed 35 ± 23%, 29 ± 20%, and 33 ± 22% increase in gray matter, white matter, and whole brain, respectively. Based on these findings, the proposed noninvasive AIF method provides robust CBF measurement with 15O-H2O PET.