Details

Autor(en) / Beteiligte

• Steed, Ashley L.
• Christophi, George P.
• Kaiko, Gerard E.
• Sun, Lulu
• Goodwin, Victoria M.
• Jain, Umang
• Esaulova, Ekaterina
• Artyomov, Maxim N.
• Morales, David J.
• Holtzman, Michael J.
• Boon, Adrianus C. M.
• Lenschow, Deborah J.
• Stappenbeck, Thaddeus S.

Titel

The microbial metabolite desaminotyrosine protects from influenza through type I interferon

Ist Teil von

• Science (American Association for the Advancement of Science), 2017-08, Vol.357 (6350), p.498-502

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2017

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• The microbiota is known to modulate the host response to influenza infection through as-yet-unclear mechanisms. We hypothesized that components of the microbiota exert effects through type I interferon (IFN), a hypothesis supported by analysis of influenza in a gain-of-function genetic mouse model. Here we show that a microbially associated metabolite, desaminotyrosine (DAT), protects from influenza through augmentation of type I IFN signaling and diminution of lung immunopathology. A specific human-associated gut microbe, Clostridium orbiscindens, produced DAT and rescued antibiotic-treated influenza-infected mice. DAT protected the host by priming the amplification loop of type I IFN signaling. These findings show that specific components of the enteric microbiota have distal effects on responses to lethal infections through modulation of type I IFN.