Details

Autor(en) / Beteiligte

• Rasche, M
• von Neuhoff, C
• Dworzak, M
• Bourquin, J-P
• Bradtke, J
• Göhring, G
• Escherich, G
• Fleischhack, G
• Graf, N
• Gruhn, B
• Haas, O A
• Klingebiel, T
• Kremens, B
• Lehrnbecher, T
• von Stackelberg, A
• Tchinda, J
• Zemanova, Z
• Thiede, C
• von Neuhoff, N
• Zimmermann, M
• Creutzig, U
• Reinhardt, D

Titel

Genotype-outcome correlations in pediatric AML: the impact of a monosomal karyotype in trial AML-BFM 2004

Ist Teil von

• Leukemia, 2017-12, Vol.31 (12), p.2807-2814

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• We conducted a cytogenetic analysis of 642 children with de novo acute myeloid leukemia (AML) treated on the AML-Berlin-Frankfurt-Münster (BFM) 04 protocol to determine the prognostic value of specific chromosomal aberrations including monosomal (MK ), complex (CK ) and hypodiploid (HK ) karyotypes, individually and in combination. Multivariate regression analysis identified in particular MK (n=22) as a new independent risk factor for poor event-free survival (EFS 23±9% vs 53±2% for all other patients, P=0.0003), even after exclusion of four patients with monosomy 7 (EFS 28±11%, P=0.0081). CK patients without MK had a better prognosis (n=47, EFS 47±8%, P=0.46) than those with MK (n=12, EFS 25±13%, P=0.024). HK (n=37, EFS 44±8% for total cohort, P=0.3) influenced outcome only when t(8;21) patients were excluded (remaining n=16, EFS 9±8%, P<0.0001). An extremely poor outcome was observed for MK /HK patients (n=10, EFS 10±10%, P<0.0001). Finally, isolated trisomy 8 was also associated with low EFS (n=16, EFS 25±11%, P=0.0091). In conclusion, monosomal karyotype is a strong and independent predictor for high-risk pediatric AML. In addition, isolated trisomy 8 and hypodiploidy without t(8;21) coincide with dismal outcome. These results have important implications for risk stratification and should be further validated in independent pediatric cohorts.