Details

Autor(en) / Beteiligte

• Wilkes, Mark C.
• Repellin, Claire E.
• Sakamoto, Kathleen M.

Titel

Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis

Ist Teil von

• Molecular genetics and metabolism, 2017-11, Vol.122 (3), p.28-38

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The role of non-coding Ribonucleic Acids (ncRNAs) in biology is currently an area of intense focus. Hematopoiesis requires rapidly changing regulatory molecules to guide appropriate differentiation and ncRNA are well suited for this. It is not surprising that virtually all aspects of hematopoiesis have roles for ncRNAs assigned to them and doubtlessly much more await characterization. Stem cell maintenance, lymphoid, myeloid and erythroid differentiation are all regulated by various ncRNAs, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and various transposable elements within the genome. As our understanding of the many and complex ncRNA roles continues to grow, new discoveries are challenging the existing classification schemes. In this review we briefly overview the broad categories of ncRNAs and discuss a few examples regulating normal and aberrant hematopoiesis. •Define the current classification schemes of non-coding RNA and examine trends and challenges facing these schemes.•Examine the cellular roles of non-coding RNA, with an emphasis on hematopoiesis.•Examine the contribution of pseudogenes, retrotransposons, sORFs and micropeptides on hematopoiesis.