Details

Autor(en) / Beteiligte

• Bardina, Susana V.
• Bunduc, Paul
• Tripathi, Shashank
• Duehr, James
• Frere, Justin J.
• Brown, Julia A.
• Nachbagauer, Raffael
• Foster, Gregory A.
• Krysztof, David
• Tortorella, Domenico
• Stramer, Susan L.
• García-Sastre, Adolfo
• Krammer, Florian
• Lim, Jean K.

Titel

Enhancement of Zika virus pathogenesis by preexisting antiflavivirus immunity

Ist Teil von

• Science (American Association for the Advancement of Science), 2017-04, Vol.356 (6334), p.175-180

Ort / Verlag

United States: American Association for the Advancement of Science

Erscheinungsjahr

2017

Link zum Volltext

Quelle

American Association for the Advancement of Science

Beschreibungen/Notizen

• Zika virus (ZIKV) is spreading rapidly into regions around the world where other flaviviruses, such as dengue virus (DENV) and West Nile virus (WNV), are endemic. Antibody-dependent enhancement has been implicated in more severe forms of flavivirus disease, but whether this also applies to ZIKV infection is unclear. Using convalescent plasma from DENV- and WNV-infected individuals, we found substantial enhancement of ZIKV infection in vitro that was mediated through immunoglobulin G engagement of Fcγ receptors. Administration of DENV- or WNV-convalescent plasma into ZIKV-susceptible mice resulted in increased morbidity—including fever, viremia, and viral loads in spinal cord and testes—and increased mortality. Antibody-dependent enhancement may explain the severe disease manifestations associated with recent ZIKV outbreaks and highlights the need to exert great caution when designing flavivirus vaccines.