Details

Autor(en) / Beteiligte

• Assiri, Abdullah M.
• Midgley, Claire M.
• Abedi, Glen R.
• Saeed, Abdulaziz Bin
• Almasri, Malak M.
• Lu, Xiaoyan
• Al-Abdely, Hail M.
• Abdalla, Osman
• Mohammed, Mutaz
• Algarni, Homoud S.
• Alhakeem, Raafat F.
• Sakthivel, Senthilkumar K.
• Nooh, Randa
• Alshayab, Zainab
• Alessa, Mohammad
• Srinivasamoorthy, Ganesh
• AlQahtani, Saeed Yahya
• Kheyami, Ali
• HajOmar, Waleed Husein
• Banaser, Talib M.
• Esmaeel, Ahmad
• Hall, Aron J.
• Curns, Aaron T.
• Tamin, Azaibi
• Alsharef, Ali Abraheem
• Erdman, Dean
• Watson, John T.
• Gerber, Susan I.

Titel

Epidemiology of a Novel Recombinant Middle East Respiratory Syndrome Coronavirus in Humans in Saudi Arabia

Ist Teil von

• The Journal of infectious diseases, 2016-09, Vol.214 (5), p.712-721

Ort / Verlag

United States: Oxford University Press

Erscheinungsjahr

2016

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Background. Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe respiratory illness in humans. Fundamental questions about circulating viruses and transmission routes remain. Methods. We assessed routinely collected epidemiologie data for MERS-CoV cases reported in Saudi Arabia during 1 January—30 June 2015 and conducted a more detailed investigation of cases reported during February 2015. Available respiratory specimens were obtained for sequencing. Results. During the study period, 216 MERS-CoV cases were reported. Full genome (n = 17) or spike gene sequences (n = 82) were obtained from 99 individuals. Most sequences (72 of 99 [73%]) formed a discrete, novel recombinant subclade (NRC-2015), which was detected in 6 regions and became predominant by June 2015. No clinical differences were noted between dades. Among 87 cases reported during February 2015, 13 had no recognized risks for secondary acquisition; 12 of these 13 also denied camel contact. Most viruses (8 of 9) from these 13 individuals belonged to NRC-2015. Discussions. Our findings document the spread and eventual predominance of NRC-2015 in humans in Saudi Arabia during the first half of 2015. Our identification of cases without recognized risk factors but with similar virus sequences indicates the need for better understanding of risk factors for MERS-CoV transmission.