Details

Autor(en) / Beteiligte

• Valdés-Rives, Silvia Anahi
• Casique-Aguirre, Diana
• Germán-Castelán, Liliana
• Velasco-Velázquez, Marco A.
• González-Arenas, Aliesha
• Pasqualetti, Francesco

Titel

Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications

Ist Teil von

• BioMed research international, 2017-01, Vol.2017, p.7403747-12

Ort / Verlag

United States: Hindawi

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Glioblastoma multiforme (GBM) is the most hostile type of brain cancer. Its aggressiveness is due to increased invasion, migration, proliferation, angiogenesis, and a decreased apoptosis. In this review, we discuss the role of key regulators of apoptosis in GBM and glioblastoma stem cells. Given their importance in the etiology and pathogenesis of GBM, these signaling molecules may represent potential therapeutic targets.