Details

Autor(en) / Beteiligte

• Willy, N M
• Ferguson, J P
• Huber, S D
• Heidotting, S P
• Aygün, E
• Wurm, S A
• Johnston-Halperin, E
• Poirier, M G
• Kural, C
• Mogilner, Alex

Titel

Membrane mechanics govern spatiotemporal heterogeneity of endocytic clathrin coat dynamics

Ist Teil von

• Molecular biology of the cell, 2017-11, Vol.28 (24), p.3480-3488

Ort / Verlag

United States: The American Society for Cell Biology

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Dynamics of endocytic clathrin-coated structures can be remarkably divergent across different cell types, cells within the same culture, or even distinct surfaces of the same cell. The origin of this astounding heterogeneity remains to be elucidated. Here we show that cellular processes associated with changes in effective plasma membrane tension induce significant spatiotemporal alterations in endocytic clathrin coat dynamics. Spatiotemporal heterogeneity of clathrin coat dynamics is also observed during morphological changes taking place within developing multicellular organisms. These findings suggest that tension gradients can lead to patterning and differentiation of tissues through mechanoregulation of clathrin-mediated endocytosis.