Details

Autor(en) / Beteiligte

• Kim, Kyoung-Han
• Kim, Yun Hye
• Son, Joe Eun
• Lee, Ju Hee
• Kim, Sarah
• Choe, Min Seon
• Moon, Joon Ho
• Zhong, Jian
• Fu, Kiya
• Lenglin, Florine
• Yoo, Jeong-Ah
• Bilan, Philip J
• Klip, Amira
• Nagy, Andras
• Kim, Jae-Ryong
• Park, Jin Gyoon
• Hussein, Samer Mi
• Doh, Kyung-Oh
• Hui, Chi-Chung
• Sung, Hoon-Ki

Titel

Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage

Ist Teil von

• Cell research, 2017-11, Vol.27 (11), p.1309-1326

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Intermittent fasting （IF）, a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanisms of IF-mediated metabolic benefits is limited. Here we show that isocaloric IF improves metabolic homeostasis against diet-induced obesity and metabolic dysfunction primarily through adipose thermogenesis in mice. IF-induced metabolic benefits require fasting-mediated increases of vascular endothelial growth factor （VEGF） expression in white adipose tissue （WAT）. Furthermore, periodic adipose-VEGF overexpression could recapitulate the metabolic improvement of IF in non-fasted animals. Importantly, fasting and adipose-VEGF induce alternative activation of adipose macrophage, which is critical for thermogenesis. Human adipose gene analysis further revealed a positive correlation of adipose VEGF-M2 macrophage-WAT browning axis. The present study uncovers the molecular mechanism of IF-mediated metabolic benefit and suggests that isocaloric IF can be a preventive and therapeutic approach against obesity and metabolic disorders.