Journal of diabetes investigation, 2017-11, Vol.8 (6), p.726-734
2017
Details
- Autor(en) / Beteiligte
- Titel
- Forkhead box class O family member proteins: The biology and pathophysiological roles in diabetes
- Ist Teil von
- Journal of diabetes investigation, 2017-11, Vol.8 (6), p.726-734
- Ort / Verlag
- Japan: John Wiley & Sons, Inc
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- Wiley Online Library All Journals
- Beschreibungen/Notizen
- Forkhead box class O family member proteins (FoxOs) of transcription factors are essential regulators of cellular homeostasis, including glucose and lipid metabolism, oxidative stress response and redox signaling, cell cycle progression, and apoptosis. Altered FoxO1 expression and activity have been associated with glucose intolerance, dyslipidemia and complications of diabetes. In the liver, they direct carbons to glucose or lipid utilization, thus providing a unifying mechanism for the two abnormalities of the diabetic liver: excessive glucose production, and increased lipid synthesis and secretion. In the pancreas, FoxO1 is necessary to maintain β‐cell differentiation, and could be promising targets for β‐cell regeneration. In endothelial cells, FoxOs strongly promote atherosclerosis through suppressing nitric oxide production and enhancing inflammatory responses. In the present review, we summarize the basic biology and pathophysiological significance of FoxOs in diabetes. Forkhead box class O family member proteins (FoxOs) of transcription factors are essential regulators of cellular homeostasis, including glucose and lipid metabolism, oxidative stress response and redox signaling, cell cycle progression and apoptosis. We summarize the basic biology and pathophysiological significance of FoxOs in diabetes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2040-1116eISSN: 2040-1124DOI: 10.1111/jdi.12651Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5668485
- Format
- –
- Schlagworte
- Apoptosis, Arteriosclerosis, Beta cells, Cell cycle, Diabetes, Diabetes mellitus, Diabetes Mellitus - metabolism, Diabetes Mellitus - physiopathology, Dyslipidemia, Endothelial cells, Forkhead box class O family member proteins, Forkhead protein, Forkhead Transcription Factors - genetics, Forkhead Transcription Factors - metabolism, Forkhead Transcription Factors - physiology, FOXO1 protein, Gene Expression Regulation, Glucose, Glucose - metabolism, Glucose Intolerance - metabolism, Glucose tolerance, Homeostasis, Humans, Inflammation, Insulin signaling, Insulin-Secreting Cells - metabolism, Insulin-Secreting Cells - physiology, Intolerance, Lipid Metabolism, Lipids, Liver, Nitric oxide, Oxidative metabolism, Oxidative stress, Pancreas, Pancreas - metabolism, Review, RNA Processing, Post-Transcriptional, Secretion, Signal Transduction, Transcription factors