Details

Autor(en) / Beteiligte

• Livny, Abigail
• Ravona-Springer, Ramit
• Heymann, Anthony
• Priess, Rachel
• Kushnir, Tammar
• Tsarfaty, Galia
• Rabinov, Leeron
• Moran, Reut
• Tik, Niv
• Moshier, Erin
• Cooper, Itzik
• Greenbaum, Lior
• Silverman, Jeremy
• Levy, Andrew
• Sano, Mary
• Bendlin, Barbara B
• Buchman, Aron S
• Schnaider-Beeri, Michal

Titel

Haptoglobin 1-1 Genotype Modulates the Association of Glycemic Control With Hippocampal Volume in Elderly Individuals With Type 2 Diabetes

Ist Teil von

• Diabetes (New York, N.Y.), 2017-11, Vol.66 (11), p.2927-2932

Ort / Verlag

United States: American Diabetes Association

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Recent evidence suggests that glycemic control is associated with cognitive function in older patients with type 2 diabetes who are carriers of the haptoglobin (Hp) 1-1 genotype compared with noncarriers. We assessed whether poor glycemic control in Hp 1-1 carriers is more strongly associated with smaller hippocampal volume than in noncarriers. Hippocampal volume was generated from high-resolution structural T1 MRI obtained for 224 participants (28 Hp 1-1 carriers [12.5%] and 196 noncarriers [87.5%]) from the Israel Diabetes and Cognitive Decline (IDCD) study, who had a mean (SD) number of years in the Maccabi Healthcare Services (MHS) registry of 8.35 (2.63) and a mean (SD) HbA level of 6.66 (0.73)% [49 mmol/mol]. A stronger negative association between right hippocampal volume and HbA was found in patients with the Hp 1-1 genotype, with a 0.032-mL decrease in right hippocampal volume per 14% increase in HbA ( = 0.0007) versus a 0.009-mL decrease in Hp 1-1 noncarriers ( = 0.047), after adjusting for total intracranial volume, age, sex, follow-up years in the registry, and cardiovascular factor (interaction, = 0.025). This indicates that 29.66% of the total variance in right hippocampal volume is explained by HbA levels among Hp 1-1 carriers and that 3.22% is explained by HbA levels among Hp 1-1 noncarriers. Our results suggest that the hippocampus of Hp 1-1 carriers may be more vulnerable to the insults of poor glycemic control.