Details

Autor(en) / Beteiligte

• Owolabi, Mayowa
• Ogbole, Godwin
• Akinyemi, Rufus
• Salaam, Kehinde
• Akpa, Onoja
• Mongkolwat, Pattanasak
• Omisore, Adeleye
• Agunloye, Atinuke
• Efidi, Richard
• Odo, Joseph
• Makanjuola, Akintomiwa
• Akpalu, Albert
• Sarfo, Fred
• Owolabi, Lukman
• Obiako, Reginald
• Wahab, Kolawole
• Sanya, Emmanuel
• Adebayo, Philip
• Komolafe, Morenikeji
• Adeoye, Abiodun Moshood
• Fawale, Michael B
• Akinyemi, Joshua
• Osaigbovo, Godwin
• Sunmonu, Taofiki
• Olowoyo, Paul
• Chukwuonye, Innocent
• Obiabo, Yahaya
• Ibinaiye, Philip
• Dambatta, Abdul
• Mensah, Yaw
• Abdul, Salaam
• Olabinri, Eunice
• Ikubor, Joyce
• Oyinloye, Olalekan
• Odunlami, Femi
• Melikam, Ezinne
• Saulson, Raelle
• Kolo, Philip
• Ogunniyi, Adesola
• Ovbiagele, Bruce

Titel

Development and Reliability of a User-Friendly Multicenter Phenotyping Application for Hemorrhagic and Ischemic Stroke

Ist Teil von

• Journal of stroke and cerebrovascular diseases, 2017-11, Vol.26 (11), p.2662-2670

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Annotation and Image Markup on ClearCanvas Enriched Stroke–phenotyping Software (ACCESS) is a novel stand-alone computer software application that allows the creation of simple standardized annotations for reporting brain images of all stroke types. We developed the ACCESS application and determined its inter-rater and intra-rater reliability in the Stroke Investigative Research and Educational Network (SIREN) study to assess its suitability for multicenter studies. One hundred randomly selected stroke imaging reports from 5 SIREN sites were re-evaluated by 4 trained independent raters to determine the inter-rater reliability of the ACCESS (version 12.0) software for stroke phenotyping. To determine intra-rater reliability, 6 raters reviewed the same cases previously reported by them after a month of interval. Ischemic stroke was classified using the Oxfordshire Community Stroke Project (OCSP), Trial of Org 10172 in Acute Stroke Treatment (TOAST), and Atherosclerosis, Small-vessel disease, Cardiac source, Other cause (ASCO) protocols, while hemorrhagic stroke was classified using the Structural lesion, Medication, Amyloid angiopathy, Systemic disease, Hypertensive angiopathy and Undetermined (SMASH-U) protocol in ACCESS. Agreement among raters was measured with Cohen's kappa statistics. For primary stroke type, inter-rater agreement was .98 (95% confidence interval [CI], .94-1.00), while intra-rater agreement was 1.00 (95% CI, 1.00). For OCSP subtypes, inter-rater agreement was .97 (95% CI, .92-1.00) for the partial anterior circulation infarcts, .92 (95% CI, .76-1.00) for the total anterior circulation infarcts, and excellent for both lacunar infarcts and posterior circulation infarcts. Intra-rater agreement was .97 (.90-1.00), while inter-rater agreement was .93 (95% CI, .84-1.00) for TOAST subtypes. Inter-rater agreement ranged between .78 (cardioembolic) and .91 (large artery atherosclerotic) for ASCO subtypes and was .80 (95% CI, .56-1.00) for SMASH-U subtypes. The ACCESS application facilitates a concordant and reproducible classification of stroke subtypes by multiple investigators, making it suitable for clinical use and multicenter research.