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Functional integrity in children with anoxic brain injury from drowning
Human brain mapping, 2017-10, Vol.38 (10), p.4813-4831
Ishaque, Mariam
Manning, Janessa H.
Woolsey, Mary D.
Franklin, Crystal G.
Tullis, Elizabeth W.
Beckmann, Christian F.
Fox, Peter T.
2017
Details
Autor(en) / Beteiligte
Ishaque, Mariam
Manning, Janessa H.
Woolsey, Mary D.
Franklin, Crystal G.
Tullis, Elizabeth W.
Beckmann, Christian F.
Fox, Peter T.
Titel
Functional integrity in children with anoxic brain injury from drowning
Ist Teil von
Human brain mapping, 2017-10, Vol.38 (10), p.4813-4831
Ort / Verlag
United States: John Wiley & Sons, Inc
Erscheinungsjahr
2017
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Drowning is a leading cause of accidental injury and death in young children. Anoxic brain injury (ABI) is a common consequence of drowning and can cause severe neurological morbidity in survivors. Assessment of functional status and prognostication in drowning victims can be extremely challenging, both acutely and chronically. Structural neuroimaging modalities (CT and MRI) have been of limited clinical value. Here, we tested the utility of resting‐state functional MRI (rs‐fMRI) for assessing brain functional integrity in this population. Eleven children with chronic, spastic quadriplegia due to drowning‐induced ABI were investigated. All were comatose immediately after the injury and gradually regained consciousness, but with varying ability to communicate their cognitive state. Eleven neurotypical children matched for age and gender formed the control group. Resting‐state fMRI and co‐registered T1‐weighted anatomical MRI were acquired at night during drug‐aided sleep. Network integrity was quantified by independent components analysis (ICA), at both group‐ and per‐subject levels. Functional‐status assessments based on in‐home observations were provided by families and caregivers. Motor ICNs were grossly compromised in ABI patients both group‐wise and individually, concordant with their prominent motor deficits. Striking preservations of perceptual and cognitive ICNs were observed, and the degree of network preservation correlated (ρ = 0.74) with the per‐subject functional status assessments. Collectively, our findings indicate that rs‐fMRI has promise for assessing brain functional integrity in ABI and, potentially, in other disorders. Furthermore, our observations suggest that the severe motor deficits observed in this population can mask relatively intact perceptual and cognitive capabilities. Hum Brain Mapp 38:4813–4831, 2017. © 2017 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1065-9471
eISSN: 1097-0193
DOI: 10.1002/hbm.23745
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5593785
Format
–
Schlagworte
anoxic brain injury
,
Assessments
,
Brain
,
Brain - diagnostic imaging
,
Brain - physiopathology
,
Brain Injuries - diagnostic imaging
,
Brain Injuries - etiology
,
Brain Injuries - physiopathology
,
Brain injury
,
Brain mapping
,
Brain Mapping - methods
,
Child
,
Child, Preschool
,
Children
,
Cognitive ability
,
Coma
,
Consciousness
,
Disability Evaluation
,
Drowning
,
Drowning - diagnostic imaging
,
Drowning - physiopathology
,
Drownings
,
Female
,
fMRI
,
Functional magnetic resonance imaging
,
Head injuries
,
Humans
,
hypoxic–ischemic encephalopathy
,
independent components analysis
,
Integrity
,
locked‐in syndrome
,
Magnetic Resonance Imaging - methods
,
Male
,
Medical imaging
,
minimally conscious state
,
Morbidity
,
Motor task performance
,
neural networks
,
Neural Pathways - diagnostic imaging
,
Neural Pathways - physiopathology
,
Neuroimaging
,
Neurologic Examination
,
Neurology
,
Night
,
Preservation
,
Rest
,
resting state
,
rs‐fcMRI
,
rs‐fMRI
,
Sleep
,
Traumatic brain injury
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