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Uveal melanoma: From diagnosis to treatment and the science in between
Cancer, 2016-08, Vol.122 (15), p.2299-2312
Chattopadhyay, Chandrani
Kim, Dae Won
Gombos, Dan S.
Oba, Junna
Qin, Yong
Williams, Michelle D.
Esmaeli, Bita
Grimm, Elizabeth A.
Wargo, Jennifer A.
Woodman, Scott E.
Patel, Sapna P.
2016
Details
Autor(en) / Beteiligte
Chattopadhyay, Chandrani
Kim, Dae Won
Gombos, Dan S.
Oba, Junna
Qin, Yong
Williams, Michelle D.
Esmaeli, Bita
Grimm, Elizabeth A.
Wargo, Jennifer A.
Woodman, Scott E.
Patel, Sapna P.
Titel
Uveal melanoma: From diagnosis to treatment and the science in between
Ist Teil von
Cancer, 2016-08, Vol.122 (15), p.2299-2312
Ort / Verlag
United States
Erscheinungsjahr
2016
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
Melanomas of the choroid, ciliary body, and iris of the eye are collectively known as uveal melanomas. These cancers represent 5% of all melanoma diagnoses in the United States, and their age‐adjusted risk is 5 per 1 million population. These less frequent melanomas are dissimilar to their more common cutaneous melanoma relative, with differing risk factors, primary treatment, anatomic spread, molecular changes, and responses to systemic therapy. Once uveal melanoma becomes metastatic, therapy options are limited and are often extrapolated from cutaneous melanoma therapies despite the routine exclusion of patients with uveal melanoma from clinical trials. Clinical trials directed at uveal melanoma have been completed or are in progress, and data from these well designed investigations will help guide future directions in this orphan disease. Cancer 2016;122:2299–2312. © 2016 American Cancer Society. Patients with uveal melanoma often imprecisely receive the same treatment as patients with cutaneous melanoma. Because uveal melanoma is a unique subset of melanoma, its biology, immunology, and natural history demand closer investigation.
Sprache
Englisch
Identifikatoren
ISSN: 0008-543X
eISSN: 1097-0142
DOI: 10.1002/cncr.29727
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5567680
Format
–
Schlagworte
breast cancer 1‐associated protein 1 (BAP1)
,
choroidal melanoma
,
Chromosome Aberrations
,
Combined Modality Therapy
,
diagnosis
,
Early Detection of Cancer
,
Genetic Predisposition to Disease
,
Genetic Testing
,
guanine nucleotide binding protein α11 (GNA11)
,
guanine nucleotide‐binding protein Q polypeptide (GNAQ)
,
Humans
,
Melanoma - diagnosis
,
Melanoma - epidemiology
,
Melanoma - etiology
,
Melanoma - therapy
,
Mutation
,
Neoplasm Metastasis
,
Neoplasm Staging
,
ocular melanoma
,
Prognosis
,
review
,
science
,
treatment
,
Treatment Outcome
,
uveal melanoma
,
Uveal Neoplasms - diagnosis
,
Uveal Neoplasms - epidemiology
,
Uveal Neoplasms - etiology
,
Uveal Neoplasms - therapy
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