Details

Autor(en) / Beteiligte

• Ji, Wen-Jie
• Ma, Yong-Qiang
• Zhang, Xin
• Zhang, Li
• Zhang, Yi-Dan
• Su, Cheng-Cheng
• Xiang, Guo-An
• Zhang, Mei-Ping
• Lin, Zhi-Chun
• Wei, Lu-Qing
• Wang, Peizhong P
• Zhang, Zhuoli
• Li, Yu-Ming
• Zhou, Xin

Titel

Inflammatory monocyte/macrophage modulation by liposome-entrapped spironolactone ameliorates acute lung injury in mice

Ist Teil von

• Nanomedicine (London, England), 2016-06, Vol.11 (11), p.1393-1406

Ort / Verlag

England: Future Medicine Ltd

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• To examine the therapeutic/preventive potential of liposome-encapsulated spironolactone (SP; Lipo-SP) for acute lung injury (ALI) and fibrosis. Lipo-SP was prepared by the film-ultrasonic method, and physicochemical and pharmacokinetic characterized for oral administration (10 and 20 mg/kg for SP-loaded liposome; 20 mg/kg for free SP) in a mouse model bleomycin-induced ALI. Lipo-SP enhanced bioavailability of SP with significant amelioration in lung pathology. Mechanistically, SP-mediated mineralocorticoid receptor antagonism contributes to inflammatory monocyte/macrophage modulation via an inhibitory effect on Ly6C monocytosis-directed M2 polarization of alveolar macrophages. Moreover, Lipo-SP at lower dose (10 mg/kg) exhibited more improvement in body weight gain. : Our data highlight Lipo-SP as a promising approach with therapeutic/preventive potential for ALI and fibrosis.