Details

Autor(en) / Beteiligte

• Misharin, Alexander V
• Morales-Nebreda, Luisa
• Reyfman, Paul A
• Cuda, Carla M
• Walter, James M
• McQuattie-Pimentel, Alexandra C
• Chen, Ching-I
• Anekalla, Kishore R
• Joshi, Nikita
• Williams, Kinola J N
• Abdala-Valencia, Hiam
• Yacoub, Tyrone J
• Chi, Monica
• Chiu, Stephen
• Gonzalez-Gonzalez, Francisco J
• Gates, Khalilah
• Lam, Anna P
• Nicholson, Trevor T
• Homan, Philip J
• Soberanes, Saul
• Dominguez, Salina
• Morgan, Vince K
• Saber, Rana
• Shaffer, Alexander
• Hinchcliff, Monique
• Marshall, Stacy A
• Bharat, Ankit
• Berdnikovs, Sergejs
• Bhorade, Sangeeta M
• Bartom, Elizabeth T
• Morimoto, Richard I
• Balch, William E
• Sznajder, Jacob I
• Chandel, Navdeep S
• Mutlu, Gökhan M
• Jain, Manu
• Gottardi, Cara J
• Singer, Benjamin D
• Ridge, Karen M
• Bagheri, Neda
• Shilatifard, Ali
• Budinger, G R Scott
• Perlman, Harris

Titel

Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span

Ist Teil von

• The Journal of experimental medicine, 2017-08, Vol.214 (8), p.2387-2404

Ort / Verlag

United States: Rockefeller University Press

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Little is known about the relative importance of monocyte and tissue-resident macrophages in the development of lung fibrosis. We show that specific genetic deletion of monocyte-derived alveolar macrophages after their recruitment to the lung ameliorated lung fibrosis, whereas tissue-resident alveolar macrophages did not contribute to fibrosis. Using transcriptomic profiling of flow-sorted cells, we found that monocyte to alveolar macrophage differentiation unfolds continuously over the course of fibrosis and its resolution. During the fibrotic phase, monocyte-derived alveolar macrophages differ significantly from tissue-resident alveolar macrophages in their expression of profibrotic genes. A population of monocyte-derived alveolar macrophages persisted in the lung for one year after the resolution of fibrosis, where they became increasingly similar to tissue-resident alveolar macrophages. Human homologues of profibrotic genes expressed by mouse monocyte-derived alveolar macrophages during fibrosis were up-regulated in human alveolar macrophages from fibrotic compared with normal lungs. Our findings suggest that selectively targeting alveolar macrophage differentiation within the lung may ameliorate fibrosis without the adverse consequences associated with global monocyte or tissue-resident alveolar macrophage depletion.