Details

Autor(en) / Beteiligte

• Cetera, Maureen
• Leybova, Liliya
• Woo, Frank W.
• Deans, Michael
• Devenport, Danelle

Titel

Planar cell polarity-dependent and independent functions in the emergence of tissue-scale hair follicle patterns

Ist Teil von

• Developmental biology, 2017-08, Vol.428 (1), p.188-203

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Hair follicles of the mammalian epidermis display local order and global alignment, a complex pattern instructed by the core planar cell polarity (PCP) pathway. Here we address the contributions of core PCP genes, Van Gogh-like and Frizzled, to the establishment, local refinement, and global order of embryonic and postnatal hair follicles. We find that, similar to Fz6 mutants, the disordered hair patterns of Vangl2 mutants are refined over time and eventually corrected. In both mutants, we find that tissue-level reorientation occurs through locally coordinated follicle rotation at stereotyped locations. Strikingly, Vangl2 and Fz6 mutant follicles collectively rotate with opposing directionalities, suggesting that redundant core PCP signals contribute to their directed realignment. Consistently, global follicle alignment is not restored upon conditional ablation of both Vangl1 and Vangl2 genes. Instead, spatially distinct patterns of whorls and crosses emerge and persist even after a complete cycle of hair follicle regeneration. Thus, local refinement of hair follicles into higher order patterns can occur independently of the core PCP system, however, their global alignment with the body axes requires PCP function throughout morphogenesis, growth and regeneration. •PCP mutant follicles correct their alignment through local stereotyped rotations.•Vangl2 and Fz6 mutant follicles rotate with opposing directionalities.•Hair follicle orientation and PCP asymmetry can be uncoupled.•Global hair follicle patterns fail to correct in the absence of Vangl1 and Vangl2.•Spatially distinct local patterns emerge independent of Vangl function.