Details

Autor(en) / Beteiligte

• Vicari, Alain P
• Schoepfer, Alain M
• Meresse, Bertrand
• Goffin, Laurence
• Léger, Olivier
• Josserand, Soheila
• Guégan, Nicolas
• Yousefi, Shida
• Straumann, Alex
• Cerf-Bensussan, Nadine
• Simon, Hans-Uwe
• Chvatchko, Yolande

Titel

Discovery and characterization of a novel humanized anti-IL-15 antibody and its relevance for the treatment of refractory celiac disease and eosinophilic esophagitis

Ist Teil von

• mAbs, 2017-08, Vol.9 (6), p.927-944

Ort / Verlag

United States: Taylor & Francis

Erscheinungsjahr

2017

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Interleukin-15 (IL-15) is a critical regulator of immune responses, especially at mucosal interfaces within the gastro-intestinal tract. Here, we describe the discovery and characterization of a humanized antibody to IL-15. Data from its epitope and mode of action, cell biology and primate pharmacology, as well as translational studies in human samples and in vivo proof-of-concept experiments in mouse models demonstrate the therapeutic potential of this new antibody targeting IL-15 for refractory celiac disease and eosinophilic esophagitis.