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Differential Activity of the Oral Glucan Synthase Inhibitor SCY-078 against Wild-Type and Echinocandin-Resistant Strains of Candida Species
Ist Teil von
Antimicrobial agents and chemotherapy, 2017-08, Vol.61 (8)
Ort / Verlag
United States: American Society for Microbiology
Erscheinungsjahr
2017
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
SCY-078 (formerly MK-3118) is a novel orally active inhibitor of fungal β-(1,3)-glucan synthase (GS). SCY-078 is a derivative of enfumafungin and is structurally distinct from the echinocandin class of antifungal agents. We evaluated the
activity of this compound against wild-type (WT) and echinocandin-resistant isolates containing mutations in the
genes of
spp. Against 36
spp.
mutants tested, 30 (83.3%) were non-WT to 1 or more echinocandins, and only 9 (25.0%) were non-WT (MIC, >WT-upper limit) to SCY-078. Among
isolates carrying
alterations, 84.0% were non-WT to the echinocandins versus only 24.0% for SCY-078. In contrast to the echinocandin comparators, the activity of SCY-078 was minimally affected by the presence of
mutations, suggesting that this agent is useful in the treatment of
infections due to echinocandin-resistant strains.