Details

Autor(en) / Beteiligte

• Pfaller, Michael A
• Messer, Shawn A
• Rhomberg, Paul R
• Borroto-Esoda, Katyna
• Castanheira, Mariana

Titel

Differential Activity of the Oral Glucan Synthase Inhibitor SCY-078 against Wild-Type and Echinocandin-Resistant Strains of Candida Species

Ist Teil von

• Antimicrobial agents and chemotherapy, 2017-08, Vol.61 (8)

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• SCY-078 (formerly MK-3118) is a novel orally active inhibitor of fungal β-(1,3)-glucan synthase (GS). SCY-078 is a derivative of enfumafungin and is structurally distinct from the echinocandin class of antifungal agents. We evaluated the activity of this compound against wild-type (WT) and echinocandin-resistant isolates containing mutations in the genes of spp. Against 36 spp. mutants tested, 30 (83.3%) were non-WT to 1 or more echinocandins, and only 9 (25.0%) were non-WT (MIC, >WT-upper limit) to SCY-078. Among isolates carrying alterations, 84.0% were non-WT to the echinocandins versus only 24.0% for SCY-078. In contrast to the echinocandin comparators, the activity of SCY-078 was minimally affected by the presence of mutations, suggesting that this agent is useful in the treatment of infections due to echinocandin-resistant strains.