Cancer and metastasis reviews, 2016-09, Vol.35 (3), p.413-426
2016
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Details
- Autor(en) / Beteiligte
- Titel
- Targeting cellular and molecular drivers of head and neck squamous cell carcinoma: current options and emerging perspectives
- Ist Teil von
- Cancer and metastasis reviews, 2016-09, Vol.35 (3), p.413-426
- Ort / Verlag
- New York: Springer US
- Erscheinungsjahr
- 2016
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Despite improvements in functional outcomes attributable to advances in radiotherapy, chemotherapy, surgical techniques, and imaging techniques, survival in head and neck squamous cell carcinoma (HNSCC) patients has improved only marginally during the last couple of decades, and optimal therapy has yet to be devised. Genomic complexity and intratumoral genetic heterogeneity may contribute to treatment resistance and the propensity for locoregional recurrence. Countering this, it demands a significant effort from both basic and clinical scientists in the search for more effective targeted therapies. Recent genomewide studies have provided valuable insights into the genetic basis of HNSCC, uncovering potential new therapeutic opportunities. In addition, several studies have elucidated how inflammatory, immune, and stromal cells contribute to the particular properties of these neoplasms. In the present review, we introduce recent findings on genomic aberrations resulting from whole-genome sequencing of HNSCC, we discuss how the particular microenvironment affects the pathogenesis of this disease, and we describe clinical trials exploring new perspectives on the use of combined genetic and cellular targeted therapies.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0167-7659eISSN: 1573-7233DOI: 10.1007/s10555-016-9625-1Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5524458
- Format
- –
- Schlagworte
- Antimitotic agents, Antineoplastic agents, Antineoplastic Agents - pharmacology, Antineoplastic Agents - therapeutic use, Automobile drivers, Biomedical and Life Sciences, Biomedicine, Cancer, Cancer Research, Carcinoma, Squamous Cell - diagnosis, Carcinoma, Squamous Cell - etiology, Carcinoma, Squamous Cell - metabolism, Carcinoma, Squamous Cell - therapy, Care and treatment, Cell Transformation, Neoplastic - genetics, Chemotherapy, Clinical, Gene Expression Regulation, Neoplastic - drug effects, Genetic aspects, Genetic Predisposition to Disease, Genetic Variation, Genomes, Genomics, Head and Neck Neoplasms - diagnosis, Head and Neck Neoplasms - etiology, Head and Neck Neoplasms - metabolism, Head and Neck Neoplasms - therapy, Health aspects, Humans, Molecular Targeted Therapy, Neoplasm Grading, Oncology, Protein Kinase Inhibitors - pharmacology, Protein Kinase Inhibitors - therapeutic use, Radiotherapy, Signal Transduction - drug effects, Squamous cell carcinoma, Squamous Cell Carcinoma of Head and Neck, Tumor Microenvironment - drug effects, Tumor Microenvironment - genetics