Diabetes (New York, N.Y.), 2017-08, Vol.66 (8), p.2137-2143
2017
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- Autor(en) / Beteiligte
- Titel
- Cationic Polystyrene Resolves Nonalcoholic Steatohepatitis, Obesity, and Metabolic Disorders by Promoting Eubiosis of Gut Microbiota and Decreasing Endotoxemia
- Ist Teil von
- Diabetes (New York, N.Y.), 2017-08, Vol.66 (8), p.2137-2143
- Ort / Verlag
- United States: American Diabetes Association
- Erscheinungsjahr
- 2017
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A pandemic of metabolic diseases, consisting of type 2 diabetes, nonalcoholic fatty liver disease, and obesity, has imposed critical challenges for societies worldwide, prompting investigation of underlying mechanisms and exploration of low-cost and effective treatment. In this report, we demonstrate that metabolic disorders in mice generated by feeding with a high-fat diet without dietary vitamin D can be prevented by oral administration of polycationic amine resin. Oral administration of cholestyramine, but not the control uncharged polystyrene, was able to sequester negatively charged bacterial endotoxin in the gut, leading to ) reduced plasma endotoxin levels, ) resolved systemic inflammation and hepatic steatohepatitis, and ) improved insulin sensitivity. Gut dysbiosis, characterized as an increase of the phylum Firmicutes and a decrease of Bacteroidetes and was fully corrected by cholestyramine, indicating that the negatively charged components in the gut are critical for the dysbiosis. Furthermore, fecal bacteria transplant, derived from cholestyramine-treated animals, was sufficient to antagonize the metabolic disorders of the recipient mice. These results indicate that the negatively charged components produced by dysbiosis are critical for biogenesis of metabolic disorders and also show a potential application of cationic polystyrene to treat metabolic disorders through promoting gut eubiosis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0012-1797eISSN: 1939-327XDOI: 10.2337/db17-0070Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5521855
- Format
- –
- Schlagworte
- Administration, Oral, Animals, Bacteria, Cation Exchange Resins - administration & dosage, Diabetes, Diabetes mellitus, Diet, High-Fat - adverse effects, Dysbacteriosis, Dysbiosis - drug therapy, Dysbiosis - microbiology, Endotoxemia, Endotoxemia - drug therapy, Endotoxemia - microbiology, Endotoxins - blood, Fatty liver, Fecal Microbiota Transplantation - methods, Gastrointestinal Microbiome - drug effects, High fat diet, Insulin, Insulin Resistance, Intestinal microflora, Liver diseases, Male, Medical treatment, Metabolic Diseases - microbiology, Metabolic Diseases - therapy, Metabolic disorders, Metabolism, Mice, Inbred C57BL, Non-alcoholic Fatty Liver Disease - drug therapy, Non-alcoholic Fatty Liver Disease - microbiology, Obesity, Obesity - drug therapy, Obesity - microbiology, Oral administration, Pandemics, Polystyrene, Polystyrenes - administration & dosage, Symbiosis - drug effects, Treatment Outcome, Vitamin D