Nature medicine, 2013-03, Vol.19 (3), p.291-294
2013
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction
- Ist Teil von
- Nature medicine, 2013-03, Vol.19 (3), p.291-294
- Ort / Verlag
- United States: Nature Publishing Group
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Enhanced fetal γ-globin synthesis alleviates symptoms of β-globinopathies such as sickle cell disease and β-thalassemia, but current γ-globin-inducing drugs offer limited beneficial effects. We show here that lysine-specific demethylase 1 (LSD1) inhibition by RNAi in human erythroid cells or by the monoamine oxidase inhibitor tranylcypromine in human erythroid cells or β-type globin-transgenic mice enhances γ-globin expression. LSD1 is thus a promising therapeutic target for γ-globin induction, and tranylcypromine may serve as a lead compound for the development of a new γ-globin inducer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1078-8956eISSN: 1546-170XDOI: 10.1038/nm.3101Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5512162
- Format
- –
- Schlagworte
- Anemia, Sickle Cell - genetics, Anemia, Sickle Cell - therapy, Animals, beta-Globins - genetics, beta-Thalassemia - genetics, beta-Thalassemia - therapy, Care and treatment, Cell Differentiation, Cells, Cultured, Epigenetics, Erythroid Cells - drug effects, Erythroid Cells - metabolism, Fetal Hemoglobin - biosynthesis, gamma-Globins - biosynthesis, Gene expression, Genetic aspects, Health aspects, Hemoglobin, Hemoglobinopathy, Histone Demethylases - antagonists & inhibitors, Histone Demethylases - genetics, Histone Demethylases - metabolism, Humans, Inhibitor drugs, Lysine, Mice, Mice, Transgenic, Molecular Targeted Therapy, Monoamine Oxidase Inhibitors - pharmacology, Nuclear Receptor Subfamily 2, Group C, Member 1 - metabolism, Oxidases, Pharmacology, Physiological aspects, Promoter Regions, Genetic, Receptors, Steroid - metabolism, Receptors, Thyroid Hormone - metabolism, Risk factors, RNA Interference, RNA, Small Interfering, Tranylcypromine - pharmacology