The Journal of biological chemistry, 2017-07, Vol.292 (28), p.11601-11609
2017
Details
- Autor(en) / Beteiligte
- Titel
- Exploring cancer metabolism using stable isotope-resolved metabolomics (SIRM)
- Ist Teil von
- The Journal of biological chemistry, 2017-07, Vol.292 (28), p.11601-11609
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Metabolic reprogramming is a hallmark of cancer. The changes in metabolism are adaptive to permit proliferation, survival, and eventually metastasis in a harsh environment. Stable isotope-resolved metabolomics (SIRM) is an approach that uses advanced approaches of NMR and mass spectrometry to analyze the fate of individual atoms from stable isotope-enriched precursors to products to deduce metabolic pathways and networks. The approach can be applied to a wide range of biological systems, including human subjects. This review focuses on the applications of SIRM to cancer metabolism and its use in understanding drug actions.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-9258eISSN: 1083-351XDOI: 10.1074/jbc.R117.776054Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5512057
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - pharmacology, Antineoplastic Agents - therapeutic use, cancer, Carbon Isotopes, Cellular Reprogramming - drug effects, Drug Evaluation, Preclinical - methods, Drug Evaluation, Preclinical - trends, Energy Metabolism - drug effects, Fourier Analysis, Humans, isotopic tracer, Magnetic Resonance Spectroscopy, Mass Spectrometry, mass spectrometry (MS), metabolism, metabolomics, Metabolomics - methods, Metabolomics - trends, Minireviews, Neoplasms - drug therapy, Neoplasms - enzymology, Neoplasms - metabolism, Nitrogen Isotopes, nuclear magnetic resonance (NMR)