Details

Autor(en) / Beteiligte

• Liu, Wen-Bo
• Okamoto, Noriko
• Alexy, Eric J
• Hong, Allen Y
• Tran, Kristy
• Stoltz, Brian M

Titel

Enantioselective γ‑Alkylation of α,β-Unsaturated Malonates and Ketoesters by a Sequential Ir-Catalyzed Asymmetric Allylic Alkylation/Cope Rearrangement

Ist Teil von

• Journal of the American Chemical Society, 2016-04, Vol.138 (16), p.5234-5237

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• A catalytic, enantioselective γ-alkylation of α,β-unsaturated malonates and ketoesters is reported. This strategy entails a highly regio- and enantioselective iridium-catalyzed α-alkylation of an extended enolate, and a subsequent translocation of chirality to the γ-position via a Cope rearrangement.