Details

Autor(en) / Beteiligte

• Menard, Didier
• Dondorp, Arjen

Titel

Antimalarial Drug Resistance: A Threat to Malaria Elimination

Ist Teil von

• Cold Spring Harbor perspectives in medicine, 2017-07, Vol.7 (7), p.a025619

Ort / Verlag

United States: Cold Spring Harbor Laboratory Press

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Increasing antimalarial drug resistance once again threatens effective antimalarial drug treatment, malaria control, and elimination. Artemisinin combination therapies (ACTs) are first-line treatment for uncomplicated falciparum malaria in all endemic countries, yet partial resistance to artemisinins has emerged in the Greater Mekong Subregion. Concomitant emergence of partner drug resistance is now causing high ACT treatment failure rates in several areas. Genetic markers for artemisinin resistance and several of the partner drugs have been established, greatly facilitating surveillance. Single point mutations in the gene coding for the Kelch propeller domain of the K13 protein strongly correlate with artemisinin resistance. Novel regimens and strategies using existing antimalarial drugs will be needed until novel compounds can be deployed. Elimination of artemisinin resistance will imply elimination of all falciparum malaria from the same areas. In vivax malaria, chloroquine resistance is an increasing problem.