Trends in biotechnology (Regular ed.), 2017-07, Vol.35 (7), p.653-664
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Applications of pHLIP Technology for Cancer Imaging and Therapy
- Ist Teil von
- Trends in biotechnology (Regular ed.), 2017-07, Vol.35 (7), p.653-664
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2017
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Acidity is a biomarker of cancer that is not subject to the blunting clonal selection effects that reduce the efficacy of other biomarker technologies, such as antibody targeting. The pH (low) insertion peptides (pHLIP® s) provide new opportunities for targeting acidic tissues. Through the physical mechanism of membrane-associated folding, pHLIPs are triggered by the acidic microenvironment to insert and span the membranes of tumor cells. The pHLIP platform can be applied to imaging acidic tissues, delivering cell-permeable and impermeable molecules to the cytoplasm, and promoting the cellular uptake of nanoparticles. Since acidosis is a hallmark of tumor development, progression, and aggressiveness, the pHLIP technology may prove useful in targeting cancer cells and metastases for tumor diagnosis, imaging, and therapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0167-7799eISSN: 1879-3096DOI: 10.1016/j.tibtech.2017.03.014Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5492987
- Format
- –
- Schlagworte
- Acidification, Acidity, Acidosis, Amino acids, Animals, Antibodies, Neoplasm - therapeutic use, Biochemistry, Biomarkers, Biomarkers, Tumor - metabolism, Cancer, Cancer therapies, Cell growth, Cell-Penetrating Peptides - pharmacokinetics, Cell-Penetrating Peptides - therapeutic use, Clonal selection, Cytoplasm, Diagnosis, drug delivery, Drug Delivery Systems - methods, Effectiveness, Folding, Head & neck cancer, Humans, Hydrogen-Ion Concentration, Imaging, Insertion, Internal Medicine, Membranes, Metabolism, Metastases, Nanoparticles, nanotechnology, Neoplasms - diagnostic imaging, Neoplasms - drug therapy, Neoplasms - metabolism, Neoplasms - pathology, Optical Imaging - methods, Peptides, Permeability, Physiology, Technology, Therapy, Tissues, Tumor cells, tumor targeting, Tumors