Details

Autor(en) / Beteiligte

• Bots, Wouter T. C.
• Bosch, Sven
• Zwijnenburg, Ellen M.
• Dijkema, Tim
• Broek, Guido B.
• Weijs, Willem L. J.
• Verhoef, Lia C. G.
• Kaanders, Johannes H. A. M.

Titel

Reirradiation of head and neck cancer: Long‐term disease control and toxicity

Ist Teil von

• Head & neck, 2017-06, Vol.39 (6), p.1122-1130

Ort / Verlag

United States: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

Wiley Online Library - AutoHoldings Journals

Beschreibungen/Notizen

• ABSTRACT Background The purpose of this study was to report long‐term disease control and late radiation toxicity for patients reirradiated for head and neck cancer. Methods We conducted a retrospective analysis of 137 patients reirradiated with a prescribed dose ≥45 Gy between 1986 and 2013 for a recurrent or second primary malignancy. Endpoints were locoregional control, overall survival (OS), and grade ≥4 late complications according to European Organization for Research and Treatment of Cancer (EORTC)/Radiation Therapy Oncology Group (RTOG) criteria. Results Five‐year locoregional control rates were 46% for patients reirradiated postoperatively versus 20% for patients who underwent reirradiation as the primary treatment (p < .05). Sixteen cases of serious (grade ≥4) late toxicity were seen in 11 patients (actuarial 28% at 5 years). In patients reirradiated with intensity‐modulated radiotherapy (IMRT), a borderline improved locoregional control was observed (49% vs 36%; p = .07), whereas late complication rates did not differ. Conclusion Reirradiation should be considered for patients with a recurrent or second primary head and neck cancer, especially postoperatively, if indicated. © 2017 Wiley Periodicals, Inc. Head Neck 39: 1122–1130, 2017