Details

Autor(en) / Beteiligte

• Olivieri, Fabiola
• Capri, Miriam
• Bonafè, Massimiliano
• Morsiani, Cristina
• Jung, Hwa Jin
• Spazzafumo, Liana
• Viña, Jose
• Suh, Yousin

Titel

Circulating miRNAs and miRNA shuttles as biomarkers: Perspective trajectories of healthy and unhealthy aging

Ist Teil von

• Mechanisms of ageing and development, 2017-07, Vol.165 (Pt B), p.162-170

Ort / Verlag

Ireland: Elsevier B.V

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• •Trajectories of healthy aging can be traced in cross-sectional/longitudinal cohorts by having centenarians and centenarians’ offspring among last age- classes.•Type and levels of circulating-shuttled-miRs, may indicate changes towards healthy or unhealthy trajectories (age-related diseases onset).•A consensus on circulating-miR normalization procedures should be pursued.•Circulating miR-21-5p is proposed as significant biomarker to identify healthy and unhealthy trajectories taking into account its level in the blood. Human aging is a lifelong process characterized by a continuous trade-off between pro-and anti-inflammatory responses, where the best-adapted and/or remodeled genetic/epigenetic profile may develop a longevity phenotype. Centenarians and their offspring represent such a phenotype and their comparison to patients with age-related diseases (ARDs) is expected to maximize the chance to unravel the genetic makeup that better associates with healthy aging trajectories. Seemingly, such comparison is expected to allow the discovery of new biomarkers of longevity together with risk factor for the most common ARDs. MicroRNAs (miRNAs) and their shuttles (extracellular vesicles in particular) are currently conceived as those endowed with the strongest ability to provide information about the trajectories of healthy and unhealthy aging. We review the available data on miRNAs in aging and underpin the evidence suggesting that circulating miRNAs (and cognate shuttles), especially those involved in the regulation of inflammation (inflamma-miRs) may constitute biomarkers capable of reliably depicting healthy and unhealthy aging trajectories.