Details

Autor(en) / Beteiligte

• Gorter de Vries, Arthur R
• Pronk, Jack T
• Daran, Jean-Marc G
• Cullen, Daniel

Titel

Industrial Relevance of Chromosomal Copy Number Variation in Saccharomyces Yeasts

Ist Teil von

• Applied and environmental microbiology, 2017-06, Vol.83 (11), p.E03206

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Chromosomal copy number variation (CCNV) plays a key role in evolution and health of eukaryotes. The unicellular yeast is an important model for studying the generation, physiological impact, and evolutionary significance of CCNV. Fundamental studies of this yeast have contributed to an extensive set of methods for analyzing and introducing CCNV. Moreover, these studies provided insight into the balance between negative and positive impacts of CCNV in evolutionary contexts. A growing body of evidence indicates that CCNV not only frequently occurs in industrial strains of yeasts but also is a key contributor to the diversity of industrially relevant traits. This notion is further supported by the frequent involvement of CCNV in industrially relevant traits acquired during evolutionary engineering. This review describes recent developments in genome sequencing and genome editing techniques and discusses how these offer opportunities to unravel contributions of CCNV in industrial s strains as well as to rationally engineer yeast chromosomal copy numbers and karyotypes.