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The “integrated diagnosis” for infiltrating gliomas in the 2016 revised World Health Organization (WHO) classification of tumors of the central nervous system requires assessment of the tumor for
IDH
mutations and 1p/19q codeletion. Since
TERT
promoter mutations and ATRX alterations have been shown to be associated with prognosis, we analyzed whether these tumor markers provide additional prognostic information within each of the five WHO 2016 categories. We used data for 1206 patients from the UCSF Adult Glioma Study, the Mayo Clinic and The Cancer Genome Atlas (TCGA) with infiltrative glioma, grades II-IV for whom tumor status for
IDH
, 1p/19q codeletion, ATRX, and
TERT
had been determined. All cases were assigned to one of 5 groups following the WHO 2016 diagnostic criteria based on their morphologic features, and
IDH
and 1p/19q codeletion status. These groups are: (1) Oligodendroglioma,
IDH
-mutant and 1p/19q-codeleted; (2) Astrocytoma,
IDH
-mutant; (3) Glioblastoma,
IDH
-mutant; (4) Glioblastoma,
IDH
-wildtype; and (5) Astrocytoma,
IDH
-wildtype. Within each group, we used univariate and multivariate Cox proportional hazards models to assess associations of overall survival with patient age at diagnosis, grade, and ATRX alteration status and/or
TERT
promoter mutation status. Among Group 1
IDH
-mutant 1p/19q-codeleted oligodendrogliomas, the
TERT
-WT group had significantly worse overall survival than the
TERT
-MUT group (HR: 2.72, 95% CI 1.05–7.04,
p
= 0.04). In both Group 2,
IDH
-mutant astrocytomas and Group 3,
IDH
-mutant glioblastomas, neither
TERT
mutations nor ATRX alterations were significantly associated with survival. Among Group 4,
IDH
-wildtype glioblastomas, ATRX alterations were associated with favorable outcomes (HR: 0.36, 95% CI 0.17–0.81,
p
= 0.01). Among Group 5,
IDH
-wildtype astrocytomas, the
TERT
-WT group had significantly better overall survival than the
TERT
-MUT group (HR: 0.48, 95% CI 0.27–0.87),
p
= 0.02). Thus, we present evidence that in certain WHO 2016 diagnostic groups, testing for
TERT
promoter mutations or ATRX alterations may provide additional useful prognostic information.