Molecular oncology, 2016-12, Vol.10 (10), p.1497-1515
2016
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- Autor(en) / Beteiligte
- Titel
- Dysregulation of histone methyltransferases in breast cancer – Opportunities for new targeted therapies?
- Ist Teil von
- Molecular oncology, 2016-12, Vol.10 (10), p.1497-1515
- Ort / Verlag
- United States: Elsevier B.V
- Erscheinungsjahr
- 2016
- Quelle
- Wiley-Blackwell Journals
- Beschreibungen/Notizen
- Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues on histone tails and non-histone targets. These important post-translational modifications are exquisitely regulated and affect chromatin compaction and transcriptional programs leading to diverse biological outcomes. There is accumulating evidence that genetic alterations of several HMTs impinge on oncogenic or tumor-suppressor functions and influence both cancer initiation and progression. HMTs therefore represent an opportunity for therapeutic targeting in those patients with tumors in which HMTs are dysregulated, to reverse the histone marks and transcriptional programs associated with aggressive tumor behavior. In this review, we describe the known histone methyltransferases and their emerging roles in breast cancer tumorigenesis.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1574-7891eISSN: 1878-0261DOI: 10.1016/j.molonc.2016.09.003Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5423136
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - pharmacology, Antineoplastic Agents - therapeutic use, Arginine, Binding sites, Breast - drug effects, Breast - pathology, Breast cancer, Breast Neoplasms - drug therapy, Breast Neoplasms - genetics, Breast Neoplasms - metabolism, Breast Neoplasms - pathology, Chromatin, CRISPR, Deoxyribonucleic acid, DNA, DNA methylation, Drug Discovery, Enzyme Inhibitors - pharmacology, Enzyme Inhibitors - therapeutic use, Epigenesis, Genetic - drug effects, Female, Gene expression, Gene Expression Regulation, Neoplastic - drug effects, Genomes, Histone Code - drug effects, Histone methyltransferase, Histone-Lysine N-Methyltransferase - analysis, Histone-Lysine N-Methyltransferase - antagonists & inhibitors, Histone-Lysine N-Methyltransferase - genetics, Histone-Lysine N-Methyltransferase - metabolism, Humans, Inhibitors, Lysine, Medical research, Molecular Targeted Therapy, Protein-Arginine N-Methyltransferases - analysis, Protein-Arginine N-Methyltransferases - antagonists & inhibitors, Protein-Arginine N-Methyltransferases - genetics, Protein-Arginine N-Methyltransferases - metabolism, Review, Therapeutic targets, Transcription, Transcriptional Activation - drug effects, Tumorigenesis, Tumors