Clinical infectious diseases, 2017-05, Vol.64 (10), p.1453-1456
2017
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Elevated Pre—Antiretroviral Therapy CD39+CD8+T Cell Frequency Is Associated With Early Mortality in Advanced Human Immunodeficiency Virus/Tuberculosis Co-infection
- Ist Teil von
- Clinical infectious diseases, 2017-05, Vol.64 (10), p.1453-1456
- Ort / Verlag
- United States: Oxford University Press
- Erscheinungsjahr
- 2017
- Quelle
- Oxford Journals 2020 Medicine
- Beschreibungen/Notizen
- Correlates of death soon after antiretroviral therapy (ART) initiation remain unclear. We investigated the association between expression of CD39, a novel immune exhaustion marker, and early mortality in patients with human immunodeficiency virus/tuberculosis co-infection. Elevated pre-ART CD39+CD8+ T cell frequency was independently associated with mortality within 6 months of ART initiation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1058-4838eISSN: 1537-6591DOI: 10.1093/cid/cix155Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5411394
- Format
- –
- Schlagworte
- Adult, Aged, Anti-Retroviral Agents - adverse effects, Anti-Retroviral Agents - therapeutic use, Antigens, CD - genetics, Antigens, CD - immunology, Antiretroviral agents, Antiretroviral drugs, Antiretroviral therapy, Antiretroviral Therapy, Highly Active - adverse effects, Apyrase - genetics, Apyrase - immunology, Biomarkers, Botswana - epidemiology, Brief Report, BRIEF REPORTS, CD4 Lymphocyte Count, CD8 antigen, CD8-Positive T-Lymphocytes - immunology, Cells, Cohort Studies, Coinfection - mortality, Exhaustion, Female, HIV, HIV Infections - blood, HIV Infections - complications, HIV Infections - drug therapy, HIV Infections - immunology, Human immunodeficiency virus, Humans, Infections, Lymphocytes T, Male, Middle Aged, Mortality, Prospective Studies, Therapy, Tuberculosis, Tuberculosis - blood, Tuberculosis - complications, Tuberculosis - drug therapy, Tuberculosis - immunology, Viruses, Young Adult