Journal of the American Academy of Child and Adolescent Psychiatry, 2017-05, Vol.56 (5), p.383-390
2017
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Details
- Autor(en) / Beteiligte
- Titel
- Paternal Age Alters Social Development in Offspring
- Ist Teil von
- Journal of the American Academy of Child and Adolescent Psychiatry, 2017-05, Vol.56 (5), p.383-390
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2017
- Quelle
- Applied Social Sciences Index & Abstracts (ASSIA)
- Beschreibungen/Notizen
- Abstract Objective Advanced paternal age (APA) at conception has been linked with autism and schizophrenia in offspring, neurodevelopmental disorders that affect social functioning. The current study explored the effects of paternal age on social development in the general population. Method We used multilevel growth modelling to investigate APA effects on socioemotional development from early childhood until adolescence, as measured by the Strengths and Difficulties Questionnaire (SDQ) in the Twins Early Development Study (TEDS) sample. We also investigated genetic and environmental underpinnings of the paternal age effects on development, using ACE ( A dditive genetics, C ommon environment, unique E nvironment) and gene–environment (GxE) models. Results In the general population, both very young and advanced paternal ages were associated with altered trajectory of social development (intercept: p=.01; slope: p=.03). No other behavioural domain was affected by either young or advanced age at fatherhood, suggesting specificity of paternal age effects. Increased importance of genetic factors in social development was recorded in the offspring of older but not very young fathers, suggesting distinct underpinnings of the paternal age effects at these two extremes. Conclusion Our findings highlight that the APA-related deficits that lead to autism and schizophrenia are likely continuously distributed in the population.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0890-8567eISSN: 1527-5418DOI: 10.1016/j.jaac.2017.02.006Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5409803
- Format
- –
- Schlagworte
- Adolescent, Adolescents, advanced paternal age, Age, Age differences, Age Factors, Aged, Autism, Autistic Disorder - etiology, Child, Child & adolescent psychiatry, Child Development, Child psychology, Child, Preschool, Childhood, Children, Emotional development, Environment, Extremes, Fathers, Female, Gene-Environment Interaction, Genetic factors, Humans, Longitudinal Studies, Male, Mental disorders, Mental health care, Middle Aged, neurodevelopment, Neurodevelopmental disorders, Neurodevelopmental Disorders - genetics, New Research, Parents, Pediatrics, Psychiatry, Questionnaires, Risk Factors, Schizophrenia, Schizophrenia - etiology, Social Adjustment, Social behavior, Social development, Social functioning, Surveys and Questionnaires, Twins, Young Children