Details

Autor(en) / Beteiligte

• Chandrawati, Rona
• Chang, Jason Y. H.
• Reina‐Torres, Ester
• Jumeaux, Coline
• Sherwood, Joseph M.
• Stamer, W. Daniel
• Zelikin, Alexander N.
• Overby, Darryl R.
• Stevens, Molly M.

Titel

Localized and Controlled Delivery of Nitric Oxide to the Conventional Outflow Pathway via Enzyme Biocatalysis: Toward Therapy for Glaucoma

Ist Teil von

• Advanced materials (Weinheim), 2017-04, Vol.29 (16), p.np-n/a

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Nitric oxide (NO) is able to lower intraocular pressure (IOP); however, its therapeutic effects on outflow physiology are location‐ and dose‐dependent. A NO delivery platform that directly targets the resistance‐generating region of the conventional outflow pathway and locally liberates a controlled dose of NO is reported. An increase in outflow facility (decrease in IOP) is demonstrated in a mouse model.