Details

Autor(en) / Beteiligte

• Li, Chong
• Wu, Song
• Yang, Zhao
• Zhang, Xiaolong
• Zheng, Qi
• Lin, Ling
• Niu, Zexiong
• Li, Ruiqiang
• Cai, Zhiming
• Li, Lei

Titel

Single-cell exome sequencing identifies mutations in KCP, LOC440040, and LOC440563 as drivers in renal cell carcinoma stem cells

Ist Teil von

• Cell research, 2017-04, Vol.27 (4), p.590-593

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2017

Quelle

MEDLINE

Beschreibungen/Notizen

• Dear Editor, Renal cell carcinoma （RCC） accounts for-3% of adult malignancies and 90%-95% of kidney neoplasms [1]. Metastatic disease is usually resistant to radiation and chemotherapy. Immunotherapy shows limited response rates of 15% to 20% [2]. Cancer stem-like cells （CSCs） are key players in RCC initiation, development and resistance to therapy [3]. Previous studies have shown that RCC is a genetically distinct adult carcinoma with a relatively low mutation rate [4]. Sequencing analyses have revealed that some common somatic mutations are shared among RCC patients [5]. Recently, single-cell exome sequencing has been used to evaluate somatic muations in many tumor types [6]. However, a systematic effort applying this new technique to identify key driver genes in the CSCs of RCC has not been made.