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  • BibTeX
Epigenetic modification of the leptin promoter in diet-induced obese mice and the effects of N-3 polyunsaturated fatty acids
Scientific reports, 2014-06, Vol.4 (1), p.5282, Article 5282
2014

Details

Autor(en) / Beteiligte
Titel
Epigenetic modification of the leptin promoter in diet-induced obese mice and the effects of N-3 polyunsaturated fatty acids
Ist Teil von
  • Scientific reports, 2014-06, Vol.4 (1), p.5282, Article 5282
Ort / Verlag
England: Nature Publishing Group
Erscheinungsjahr
2014
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
  • We report evidence of a detailed epigenetic modification of the leptin promoter and the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs), which is closely associated with the leptin gene transcription in obesity. In the adipose tissue of diet induced obese (DIO) mice, methylation of the CpG island and the binding of methyl-CpG-binding domain protein 2 (MBD2) and DNA methyltransferases (DNMTs) at the leptin promoter are increased and RNA Pol II is decreased. Additionally, histones H3 and H4 are hypoacetylated, lysine 4 of histone H3 (H3K4) is hypomethylated and the binding of histone deacetylases (HDACs) 1, 2 and 6 is increased at the leptin promoter in the DIO mice. These modifications may serve a feedback role to maintain leptin concentrations within a normal range. The regulation of leptin transcriptional expression by n-3 PUFAs is mediated, at least in part, by epigenetic targets, such as MBD2 and histone modifications.
Sprache
Englisch
Identifikatoren
ISSN: 2045-2322
eISSN: 2045-2322
DOI: 10.1038/srep05282
Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5381469
Format
–
Schlagworte
Acetylation - drug effects, Adipose tissue, Animals, CpG islands, CpG Islands - genetics, Diet, High-Fat - adverse effects, DNA (Cytosine-5-)-Methyltransferases - metabolism, DNA methylation, DNA Methylation - drug effects, DNA-Binding Proteins - metabolism, DNA-directed RNA polymerase, Epigenesis, Genetic - drug effects, Epigenetics, Fatty acids, Fatty Acids, Omega-3 - administration & dosage, Fatty Acids, Omega-3 - pharmacology, Feedback, Gene Expression - drug effects, Gene regulation, Histone Deacetylases - metabolism, Histone H3, Histones, Histones - metabolism, Leptin, Leptin - genetics, Leptin - metabolism, Lysine, Male, Methylation - drug effects, Mice, Inbred C57BL, Obesity, Obesity - etiology, Obesity - genetics, Polyunsaturated fatty acids, Promoter Regions, Genetic - genetics, Protein Binding - drug effects, Reverse Transcriptase Polymerase Chain Reaction, Ribonucleic acid, RNA, RNA Polymerase II - metabolism, Rodents, Transcription

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