Details

Autor(en) / Beteiligte

• Shin, Gunchul
• Gomez, Adrian M.
• Al-Hasani, Ream
• Jeong, Yu Ra
• Kim, Jeonghyun
• Xie, Zhaoqian
• Banks, Anthony
• Lee, Seung Min
• Han, Sang Youn
• Yoo, Chul Jong
• Lee, Jong-Lam
• Lee, Seung Hee
• Kurniawan, Jonas
• Tureb, Jacob
• Guo, Zhongzhu
• Yoon, Jangyeol
• Park, Sung-Il
• Bang, Sang Yun
• Nam, Yoonho
• Walicki, Marie C.
• Samineni, Vijay K.
• Mickle, Aaron D.
• Lee, Kunhyuk
• Heo, Seung Yun
• McCall, Jordan G.
• Pan, Taisong
• Wang, Liang
• Feng, Xue
• Kim, Tae-il
• Kim, Jong Kyu
• Li, Yuhang
• Huang, Yonggang
• Gereau, Robert W.
• Ha, Jeong Sook
• Bruchas, Michael R.
• Rogers, John A.

Titel

Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics

Ist Teil von

• Neuron (Cambridge, Mass.), 2017-02, Vol.93 (3), p.509-521.e3

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• In vivo optogenetics provides unique, powerful capabilities in the dissection of neural circuits implicated in neuropsychiatric disorders. Conventional hardware for such studies, however, physically tethers the experimental animal to an external light source, limiting the range of possible experiments. Emerging wireless options offer important capabilities that avoid some of these limitations, but the current size, bulk, weight, and wireless area of coverage is often disadvantageous. Here, we present a simple but powerful setup based on wireless, near-field power transfer and miniaturized, thin, flexible optoelectronic implants, for complete optical control in a variety of behavioral paradigms. The devices combine subdermal magnetic coil antennas connected to microscale, injectable light-emitting diodes (LEDs), with the ability to operate at wavelengths ranging from UV to blue, green-yellow, and red. An external loop antenna allows robust, straightforward application in a multitude of behavioral apparatuses. The result is a readily mass-producible, user-friendly technology with broad potential for optogenetics applications. •Subdermal, wireless optogenetic platform for untethered neuronal control•Thin, flexible devices for discrete spatio-temporal targeting of neural circuits•Low-cost, reliable NFC technology adaptable to most common behavioral contexts•NFC devices can be tailored for use with different wavelength opsins in vivo Shin et al. develop fully wireless and flexible optoelectronic implants for optogenetic control in a variety of behavioral apparatuses. The results demonstrate a readily mass-producible, user-friendly technology with broad potential in studies of neural circuits in freely moving animal behavior.