Brain, behavior, and immunity, 2017-05, Vol.62, p.11-23
2017
Details
- Autor(en) / Beteiligte
- Titel
- The placental interleukin-6 signaling controls fetal brain development and behavior
- Ist Teil von
- Brain, behavior, and immunity, 2017-05, Vol.62, p.11-23
- Ort / Verlag
- Netherlands: Elsevier Inc
- Erscheinungsjahr
- 2017
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • IL-6 downstream signaling is activated in specific regions of fetal hindbrain after MIA. • Placental IL-6Rα knockout prevents MIA induced inflammatory responses in placental-fetal axis. • MIA-induced behavioral abnormalities are prevented in placental IL-6Rα knockout mice. • MIA-induced cerebellar neuropathologies are prevented in placental IL-6Rα knockout mice.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0889-1591eISSN: 1090-2139DOI: 10.1016/j.bbi.2016.11.007Titel-ID: cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5373986
- Format
- –
- Schlagworte
- Allergy and Immunology, Animals, Autism spectrum disorder (ASD), Behavior, Animal - physiology, Brain - embryology, Brain - metabolism, Female, Fetal Development - physiology, Hindbrain development, Interleukin-6 (IL-6), Interleukin-6 - metabolism, Maternal immune activation (MIA), Maternal-placental-fetal axis, Mice, Mice, Knockout, Placenta, Placenta - metabolism, Pregnancy, Psychiatry, Purkinje cells, Receptors, Interleukin-6 - genetics, Receptors, Interleukin-6 - metabolism, Signal Transduction - physiology